Marta Bofill Roig

Marta Bofill Roig

Postdoctoral researcher

Medical University of Vienna

Biography

I graduated in Mathematics at the University of Barcelona (UB) in 2014. During my bachelor degree studies, I focused my interests on topics related to Statistics. I obtained my Master’s degree in Statistics and Operations Research (MESIO UPC-UB), a joint programme by the University of Barcelona (UB) and the Universitat Politècnica de Catalunya-BarcelonaTECH (UPC), in 2016. I obtained my PhD at the Department of Statistics and Operations Research of the UPC under the supervision of Prof. Guadalupe Gómez Melis.

My research is focused on methods and software for clinical trials designs involving multiple endpoints.

My thesis dissertation is available on Zenodo.

Download my resumé

Interests

  • Clinical Trials
  • Biostatistics
  • Survival Analysis

Education

  • PhD in Statistics and Operations Research, 2020

    Universitat Politècnica de Catalunya (UPC)

  • MSc in Statistics and Operations Research (MESIO UPC-UB), 2016

    Universitat Politècnica de Catalunya (UPC) and Universitat de Barcelona (UB)

  • BSc in Mathematics, 2014

    Universitat de Barcelona (UB)

Recent Publications

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Design of phase III trials with long-term survival outcomes based on short-term binary results

Abstract: Pathologic complete response (pCR) is a common primary endpoint for a phase II trial or even accelerated approval of neoadjuvant cancer therapy. If granted, a two-arm confirmatory trial is often required to demonstrate the efficacy with a time-to-event outcome such as overall survival.
Preprint PDF Code

A general class of two-sample statistics for binary and time-to-event outcomes

Abstract: We propose a class of two-sample statistics for testing the equality of proportions and the equality of survival functions. We build our proposal on a weighted combination of a score test for the difference in proportions and a Weighted Kaplan-Meier statistic-based test for the difference of survival functions.
Preprint Code

Decision tool and Sample Size Calculator for Composite Endpoints

Summary points: This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. It discusses the relative efficiency of choosing a composite endpoint over one of its components in terms of: the frequencies of observing each component; the relative treatment effect of the tested therapy; and the association between both components.
Preprint
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Software

R packages & Shiny apps

Projects

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Llampecs de Ciència

Llampecs de Ciència es un proyecto de divulgación promovido desde el grupo de investigación GRBIO.

CompARE

CompARE is a web-platform inspired to provide help on issues relating to trials with composite endpoints.

EU-PEARL

EU-PEARL aims to create a tested and trusted framework for patient-centric integrated research platform trials

GRBIO

Research group with an expertise in Biostatistics and Bioinformatics.

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